The genetics of smoking in individuals with chronic obstructive pulmonary disease.
Obeidat M, Zhou G, Li X et al.
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Abstract
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Smoking is the principal modifiable environmental risk factor for chronic obstructive pulmonary disease (COPD) which affects 300 million people and is the 3rd leading cause of death worldwide. Most of the genetic studies of smoking have relied on self-reported smoking status which is vulnerable to reporting and recall bias. Using data from the Lung Health Study (LHS), we sought to identify genetic variants associated with quantitative smoking and cessation in individuals with mild to moderate COPD.
4,024 European ancestry individuals
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