Genome-wide association study identifies two loci influencing plasma neurofilament light levels.
Li JQ, Yuan XZ, Li HY et al.
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Plasma neurofilament light (NFL) is a promising biomarker for Alzheimer disease (AD), which increases in the early stage of AD and is associated with the progression of AD. We performed a genome-wide association study (GWAS) of plasma NFL in Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1) cohort to identify novel variants associated with AD.
176 European ancestry mild cognitive impairment cases, 172 European ancestry Alzheimer's disease cases, 179 European ancestry controls
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