A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population.
Bevilacqua L, Navarra CO, Pirastu N et al.
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Abstract
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Background and objective: Periodontitis in one of the most prevalent dental diseases. Despite numerous studies have investigated its aetiopathogenetic factors, few works have focused on its genetic predisposition and most of them took into account only candidate genes. Therefore, we conducted a Genome Wide Association Study in an Italian isolated population aimed at uncovering genetic variants that predispose to this disorder.
442 Friuli Venezia Giulia (founder/genetic isolate) cases, 160 Friuli Venezia Giulia (founder/genetic isolate) controls
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