Genome-wide meta-analysis identifies genetic locus on chromosome 9 associated with Modic changes.
Freidin M, Kraatari M, Skarp S et al.
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Abstract
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Low back pain (LBP) is a common disabling condition. Lumbar disc degeneration (LDD) may be a contributing factor for LBP. Modic change (MC), a distinct phenotype of LDD, is presented as a pathological bone marrow signal change adjacent to vertebral endplate on MRI. It is strongly associated with LBP and has heritability around 30%. Our objective was to identify genetic loci associated with MC using a genome-wide meta-analysis.
994 European ancestry cases, 835 European ancestry controls
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