Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Bentley AR, Sung YJ, Brown MR et al.
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The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
5,120 African ancestry current smoker individuals, 2,394 Asian ancestry current smoker individuals, 15,129 European ancestry current smoker individuals, 747 Hispanic current smoker individuals, 18,641 African ancestry non smoker individuals, 10,777 Asian ancestry non smoker individuals, 75,138 European ancestry non smoker individuals, 5,873 Hispanic non smoker individuals
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