Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children.
Qian M, Zhao X, Devidas M et al.
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Abstract
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Acute lymphoblastic leukemia (ALL) is the most common cancer in children and can arise in B or T lymphoid lineages. Although risk loci have been identified for B-ALL, the inherited basis of T-ALL is mostly unknown, with a particular paucity of genome-wide investigation of susceptibility variants in large patient cohorts.
157 African American child cases, 699 European ancestry child cases, 126 Hispanic child cases, 209 child cases, 12,178 European, African American and unknown ancestry controls
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