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Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 5P15.33 TERT-CLPTM1L Region.

Hung RJ, Spitz MR, Houlston RS et al.

31009812 PubMed ID
GWAS Study Type
8804 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HR
Hung RJ
SM
Spitz MR
HR
Houlston RS
SA
Schwartz AG
FJ
Field JK
YJ
Ying J
LY
Li Y
HY
Han Y
JX
Ji X
CW
Chen W
WX
Wu X
GI
Gorlov IP
NJ
Na J
DA
de Andrade M
LG
Liu G
BY
Brhane Y
DN
Diao N
WA
Wenzlaff A
DM
Davies MPA
LT
Liloglou T
TM
Timofeeva M
MT
Muley T
RH
Rennert H
SW
Saliba W
RB
Ryan BM
BE
Bowman E
BJ
Barros-Dios JM
PM
Pérez-Ríos M
MH
Morgenstern H
ZS
Zienolddiny S
SV
Skaug V
UD
Ugolini D
BS
Bonassi S
VD
van der Heijden EHFM
TA
Tardon A
BS
Bojesen SE
LM
Landi MT
JM
Johansson M
BH
Bickeböller H
AS
Arnold S
LM
Le Marchand L
MO
Melander O
AA
Andrew A
GK
Grankvist K
CN
Caporaso N
TM
Teare MD
SM
Schabath MB
AM
Aldrich MC
KL
Kiemeney LA
WH
Wichmann HE
LP
Lazarus P
MJ
Mayordomo J
NM
Neri M
HA
Haugen A
ZZ
Zhang ZF
RA
Ruano-Raviña A
BH
Brenner H
HC
Harris CC
OI
Orlow I
RG
Rennert G
RA
Risch A
BP
Brennan P
CD
Christiani DC
AC
Amos CI
YP
Yang P
GO
Gorlova OY
Chapter II

Abstract

Summary of the research findings

Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer.

1,837 European ancestry cases, 5,355 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

8804
Total Participants
GWAS
Study Type
Yes
Replicated
672 European ancestry cases, 940 European ancestry controls
Replication Participants
European
Ancestry
Canada, U.S., Germany, Netherlands, Israel, Norway, Italy, Spain, Czech Republic, Poland, Romania, Russian Federation, Denmark, Sweden, U.K., Serbia
Recruitment Country
Chapter IV

AI-Generated Summary

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