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GWAS Study

Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy.

Kerns SL, Fachal L, Dorling L et al.

31095341 PubMed ID
GWAS Study Type
3379 Participants
41 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

KS
Kerns SL
FL
Fachal L
DL
Dorling L
BG
Barnett GC
BA
Baran A
PD
Peterson DR
HM
Hollenberg M
HK
Hao K
NA
Narzo AD
AM
Ahsen ME
PG
Pandey G
BS
Bentzen SM
JM
Janelsins M
ER
Elliott RM
PP
Pharoah PDP
BN
Burnet NG
DD
Dearnaley DP
GS
Gulliford SL
HE
Hall E
SM
Sydes MR
AM
Aguado-Barrera ME
GA
Gómez-Caamaño A
CA
Carballo AM
PP
Peleteiro P
LR
Lobato-Busto R
SR
Stock R
SN
Stone NN
OH
Ostrer H
UN
Usmani N
SS
Singhal S
TH
Tsuji H
IT
Imai T
SS
Saito S
ER
Eeles R
DK
DeRuyck K
PM
Parliament M
DA
Dunning AM
VA
Vega A
RB
Rosenstein BS
WC
West CML
Chapter II

Abstract

Summary of the research findings

A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies.

3,379 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

3379
Total Participants
GWAS
Study Type
Yes
Replicated
538 Japanese ancestry individuals
Replication Participants
European, East Asian
Ancestry
Canada, U.S., Belgium, Spain, Japan
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

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