Refining genome-wide associated loci for serum uric acid in individuals with African ancestry.
Chen G, Shriner D, Doumatey AP et al.
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Abstract
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Objective: Serum uric acid is the end-product of purine metabolism and at high levels is a risk factor for several human diseases including gout and cardiovascular disease. Heritability estimates range from 0.32 to 0.63. Genome-wide association studies (GWAS) provide an unbiased approach to identify loci influencing serum uric acid. Here, we performed the first GWAS for serum uric acid in continental Africans, with replication in African Americans.
4,126 African ancestry individuals, 5,007 African American individuals
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