Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis.
Zhang H, Liu L, Ni JJ et al.
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Abstract
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Aiming to identify pleiotropic genomic loci for bone mineral density and bone size, we performed a bivariate GWAS in five discovery samples and replicated in two large-scale samples. We identified 2 novel loci at 2q37.1 and 6q26. Our findings provide insight into common genetic architecture underlying both traits.
3,267 European ancestry individuals, 1,619 Chinese ancestry individuals, 843 African American individuals, 446 Hispanic individuals
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