The genetic basis for the inverse relationship between rheumatoid arthritis and schizophrenia.
Zamanpoor M, Ghaedi H, Omrani MD
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Abstract
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Introduction: Rheumatoid arthritis is a common autoimmune disease and schizophrenia is a relatively common and debilitating neurological disorder. There are several common features between rheumatoid arthritis and schizophrenia. The inverse relationship between rheumatoid arthritis and schizophrenia has been replicated in several studies. Despite evidence for an inverse epidemiological relationship and negative correlations for risk between rheumatoid arthritis and schizophrenia, there are no biological data that directly support this inverse relationship.
29,880 European and Asian ancestry rheumatoid arthritis cases, 7,699 Chinese ancestry schizophrenia cases, 35,476 schizophrenia cases, 73,758 European and Asian ancestry controls, 18,327 Chinese ancestry controls, 46,839 controls
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