Genome-wide analysis identifies gallstone-susceptibility loci including genes regulating gastrointestinal motility.
Fairfield CJ, Drake TM, Pius R et al.
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Background and aims: Genome-wide association studies (GWAS) have identified several risk loci for gallstone disease. As with most polygenic traits, it is likely that many genetic determinants are undiscovered. The aim of this study was to identify genetic variants that represent new targets for gallstone research and treatment.
43,639 European ancestry cases, 506,798 European ancestry controls
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