Polygenic architecture and cardiovascular risk of familial combined hyperlipidemia.
Trinder M, Vikulova D, Pimstone S et al.
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Background and aims: Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid phenotypes, characterized by elevated plasma concentrations of apolipoprotein B-100 and triglycerides. The genetic inheritance of FCHL remains poorly understood. The goals of this study were to investigate the polygenetic architecture and cardiovascular risk associated with FCHL.
3,838 British ancestry cases, 345,384 British ancestry controls
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