Genetic analysis of lung cancer and the germline impact on somatic mutation burden.
Gabriel AAG, Atkins JR, Penha RCC et al.
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Abstract
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Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated susceptibility loci involved in smoking behaviors and DNA repair genes, but further work is required to identify susceptibility variants.
29,266 European ancestry lung cancer cases, 48,843 European ancestry individuals with family history of lung cancer, 251,837 European ancestry controls
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