<i>SMOC2</i> gene interacts with <i>APOL1</i> in the development of end-stage kidney disease: A genome-wide association study.
Chaudhary NS, Armstrong ND, Hidalgo BA et al.
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Abstract
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Some but not all African-Americans (AA) who carry APOL1 nephropathy risk variants (APOL1) develop kidney failure (end-stage kidney disease, ESKD). To identify genetic modifiers, we assessed gene-gene interactions in a large prospective cohort of the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.
8,074 African American or Afro-Caribbean individuals
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