Genetic diversity fuels gene discovery for tobacco and alcohol use.
Saunders GRB, Wang X, Chen F et al.
Publication Details
Comprehensive information about this research publication
Authors
Abstract
Summary of the research findings
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1-4. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries5. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.
119,589 African ancestry individuals
Study Statistics
Key metrics and study information
AI-Generated Summary
AI-generated by DNAGENICSIndependent AI summary of health and genetic findings from the published study
Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.
AI Summary In Progress
Our AI-generated summary of this publication is being prepared. Please check back soon.
Summary
Key Findings
Health Insights
Disease Analysis
Genetic Trait Analysis
Clinical Relevance
Related Publications
Other publications that may be of interest
The DNA virome varies with human genes and environments.
Kamitaki N
Nature
Torque teno virus 16 (TUS01) DNA load in blood
Evaluation of the causal relationship between smoking and schizophrenia in East Asia.
Su MH
Schizophrenia (Heidelb)
Smoking initiation
Host control of persistent Epstein-Barr virus infection.
Schmidt A
Nature
EBV read positivity (EBV-read count 1-18)
Human and bacterial genetic variation shape oral microbiomes and health.
Kamitaki N
Nature
Relative abundance of genus Peptostreptococcaceae unclassified in oral microbiome
Insights into DNA repeat expansions among 900,000 biobank participants.
Hujoel MLA
Nature
Somatic instability of CAG repeats at TCF4
Explore More Research
Discover the latest findings in health and genetic research