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GWAS Study

A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma.

Yu LL, Hu BW, Huang HX et al.

36624463 PubMed ID
GWAS Study Type
1166 Participants
80 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

YL
Yu LL
HB
Hu BW
HH
Huang HX
YB
Yu B
XQ
Xiao Q
LQ
Lv QL
LC
Luo CH
GC
Guo CX
LJ
Li JG
XX
Xie XX
YJ
Yin JY
Chapter II

Abstract

Summary of the research findings

Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma (NPC). However, due to individual differences in radiosensitivity, biomarkers are needed to tailored radiotherapy to cancer patients. However, comprehensive genome-wide radiogenomic studies on them are still lacking. The aim of this study was to identify genetic variants associated with radiotherapy response in patients with NPC.

182 cases, 137 controls

Chapter III

Study Statistics

Key metrics and study information

1166
Total Participants
GWAS
Study Type
Yes
Replicated
176 cases, 671 controls
Replication Participants
China
Recruitment Country
Chapter IV

AI-Generated Summary

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