Germline variation in RASAL2 may predict survival in patients with RAS-activated colorectal cancer.
Wills C, Watts K, Maughan TS et al.
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Abstract
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Therapeutic agents that specifically target patients with RAS mutant colorectal cancer (CRC) are needed. We sought potential drug targets by relating genome-wide association study and survival data in patients with advanced CRC profiled for mitogen-activated protein kinase (MAPK) pathway mutations.
694 European ancestry individuals
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