A genome-wide cross-trait analysis identifying shared genetic basis and causal relationships between Hunner-type interstitial cystitis and autoimmune diseases in East Asian populations.
Lyu X, Peng L, Xu X et al.
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Purpose: Epidemiological studies have demonstrated the clinical link between Hunner interstitial cystitis (HIC) and autoimmune diseases (ADs), suggesting potential shared genetic bases for their comorbidity. We aimed to investigate the shared genetic architecture and causal relationships between HIC and ADs.
153 East Asian ancestry cystitis cases, 2,472 East Asian ancestry atopic dermatitis cases, 188,279 controls
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