Validation of lung cancer polygenic risk scores in a high-risk case-control cohort.
Lebrett MB, Smith MJ, Crosbie EJ et al.
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Abstract
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Purpose: Screening with low-dose computed tomography reduces lung cancer (LC) mortality. Risk prediction models used for screening selection do not include genetic variables. Here, we investigated the performance of previously published polygenic risk scores (PRSs) for LC, considering their potential to improve screening selection.
652 European ancestry cases, 550 European ancestry high-risk ever-smoker controls
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