Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses.
Zhang L, Zhang W, He L et al.
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Abstract
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Despite epidemiological evidence associating gallstone disease (GSD) with cardiovascular disease (CVD), a dilemma remains on the role of cholecystectomy in modifying the risk of CVD. We aimed to characterize the phenotypic and genetic relationships between GSD and two CVD events - stroke and coronary artery disease (CAD).
43,639 European ancestry gall stone disease cases, 73,652 European ancestry stroke cases, 1,741,606 European ancestry controls
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