HLA signatures as pathophysiological discriminants of microscopic colitis subtypes.
Zheng T, Roda G, Zabana Y et al.
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Abstract
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Background and aims: Microscopic colitis [MC] is currently regarded as an inflammatory bowel disease that manifests as two subtypes: collagenous colitis [CC] and lymphocytic colitis [LC]. Whether these represent a clinical continuum or distinct entities is, however, an open question. Genetic investigations may contribute important insight into their respective pathophysiologies.
2,599 European ancestry cases, 552,343 European ancestry controls
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