A genome-wide association study identifying RAP1A as a novel susceptibility gene for Crohn's disease in Japanese individuals.
Kakuta Y, Kawai Y, Naito T et al.
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Background and aims: Genome-wide association studies [GWASs] of European populations have identified numerous susceptibility loci for Crohn's disease [CD]. Susceptibility genes differ by ethnicity, however, so GWASs specific for Asian populations are required. This study aimed to clarify the Japanese-specific genetic background for CD by a GWAS using the Japonica array [JPA] and subsequent imputation with the 1KJPN reference panel.
713 Japanese ancestry cases, 2,083 Japanese ancestry controls
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