Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.
Nordeidet AN, Klevjer M, Øvretveit K et al.
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Abstract
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Aims: Resting heart rate (RHR) is associated with cardiovascular disease (CVD) and mortality. This study aimed to identify genetic loci associated with RHR, develop a genome-wide polygenic risk score (PRS) for RHR, and assess associations between the RHR PRS and CVD outcomes, to better understand the biological mechanisms linking RHR to disease. Sex-specific analyses were conducted to potentially elucidate different pathways between the sexes.
550,467 European or unknown ancestry individuals
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