Rome III criteria capture higher irritable bowel syndrome SNP-heritability and highlight a novel genetic link with cardiovascular traits.
Camargo Tavares L, Lopera-Maya EA, Bonfiglio F et al.
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Background & aims: Irritable bowel syndrome (IBS) shows genetic predisposition, and large-scale genome-wide association studies (GWAS) are emerging, based on heterogeneous disease definitions. We investigated the genetic architecture of IBS defined according to gold standard Rome Criteria.
24,735 European ancestry cases, 77,149 European ancestry controls
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