Genetic associations with psychosis and affective disturbance in Alzheimer's disease.
Antonsdottir IM, Creese B, Klei L et al.
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Abstract
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Introduction: Individuals with Alzheimer's disease (AD) commonly experience neuropsychiatric symptoms of psychosis (AD+P) and/or affective disturbance (depression, anxiety, and/or irritability, AD+A). This study's goal was to identify the genetic architecture of AD+P and AD+A, as well as their genetically correlated phenotypes.
3,961 European or unknown ancestry cases, 6,027 European or unknown ancestry controls
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