Role of the X Chromosome in Alzheimer Disease Genetics.
Belloy ME, Le Guen Y, Stewart I et al.
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Abstract
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Importance: The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored genetic variation in AD.
138,558 European ancestry cases, 1,013,726 European ancestry controls
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