A genome-wide association study identifies a novel East Asian-specific locus for dementia with Lewy bodies in Japanese subjects.
Mitsumori R, Asanomi Y, Morizono T et al.
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Abstract
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Dementia with Lewy bodies (DLB) is the second most common type of degenerative dementia in older patients. As with other multifactorial diseases, the pathogenesis results from interactions of environmental and genetic factors. The genetic basis of DLB is not yet fully understood. Recent genomic analyses of DLB in Caucasian cohorts identified genetic susceptibility loci for DLB, but the comprehensive genomic analysis in Asians was still not performed.
211 Japanese ancestry cases, 6,113 Japanese ancestry controls
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