GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia.
Vattathil SM, Blostein F, Miller-Fleming TW et al.
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Abstract
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Introduction: Neuropsychiatric symptoms in dementia (NPS) collectively refer to behavioral and psychological symptoms affecting individuals with mild cognitive impairment (MCI) or Alzheimer's disease or related dementia (ADRD). NPS are among the most troubling aspects of living with dementia but their treatments have limited efficacy. We aim to investigate genetic variants contributing to NPS to identify new therapeutic targets.
7,015 European ancestry cases, 5,713 European ancestry controls
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