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GWAS Study

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

Schormair B, Zhao C, Bell S et al.

29029846 PubMed ID
GWAS Study Type
428534 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

SB
Schormair B
ZC
Zhao C
BS
Bell S
TE
Tilch E
SA
Salminen AV
PB
Pütz B
DY
Dauvilliers Y
SA
Stefani A
HB
Högl B
PW
Poewe W
KD
Kemlink D
SK
Sonka K
BC
Bachmann CG
PW
Paulus W
TC
Trenkwalder C
OW
Oertel WH
HM
Hornyak M
TM
Teder-Laving M
MA
Metspalu A
HG
Hadjigeorgiou GM
PO
Polo O
FI
Fietze I
RO
Ross OA
WZ
Wszolek Z
BA
Butterworth AS
SN
Soranzo N
OW
Ouwehand WH
RD
Roberts DJ
DJ
Danesh J
AR
Allen RP
EC
Earley CJ
OW
Ondo WG
XL
Xiong L
MJ
Montplaisir J
GZ
Gan-Or Z
PM
Perola M
VP
Vodicka P
DC
Dina C
FA
Franke A
TL
Tittmann L
SA
Stewart AFR
SS
Shah SH
GC
Gieger C
PA
Peters A
RG
Rouleau GA
BK
Berger K
OK
Oexle K
DA
Di Angelantonio E
HD
Hinds DA
MB
Müller-Myhsok B
WJ
Winkelmann J
Chapter II

Abstract

Summary of the research findings

Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets.

15,126 European ancestry cases, 95,725 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

428534
Total Participants
GWAS
Study Type
Yes
Replicated
30,770 European ancestry cases, 286,913 European ancestry controls
Replication Participants
European
Ancestry
Canada, U.S., U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.