Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.
Laje G, Allen AS, Akula N et al.
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Abstract
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Objectives: Suicidal ideation is an uncommon but worrisome symptom than can emerge during antidepressant treatment. We have described earlier the association between treatment-emergent suicidal ideation (TESI) and markers in genes encoding glutamate receptor subunits GRIK2 and GRIA3. The present genome-wide association study was conducted to identify additional genetic markers associated with TESI that may help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, and/or specialty care.
90 Hispanic and European ancestry cases, 90 Hispanic and European ancestry controls
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