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Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS.

Isackson PJ, Ochs-Balcom HM, Ma C et al.

21826682 PubMed ID
GWAS Study Type
188 Participants
88 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

IP
Isackson PJ
OH
Ochs-Balcom HM
MC
Ma C
HJ
Harley JB
PW
Peltier W
TM
Tarnopolsky M
SN
Sripathi N
WR
Wortmann RL
SZ
Simmons Z
WJ
Wilson JD
SS
Smith SA
BA
Barboi A
FE
Fine E
BA
Baer A
BS
Baker S
KK
Kaufman K
CB
Cobb B
KJ
Kilpatrick JR
VG
Vladutiu GD
Chapter II

Abstract

Summary of the research findings

Introduction: Of the nearly 38 million people in the USA who receive statin therapy, 0.1-0.5% experience severe or life-threatening myopathic side effects.

39 European ancestry severe statin myopathy cases, 40 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

188
Total Participants
GWAS
Study Type
Yes
Replicated
67 European ancestry severe statin myopathy cases, 42 European ancestry controls
Replication Participants
European
Ancestry
U.S., Australia, Canada
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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