A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.
Brown CC, Havener TM, Medina MW et al.
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Abstract
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Objective: Recently, lymphoblastoid cell lines (LCLs) have emerged as an innovative model system for mapping gene variants that predict the dose response to chemotherapy drugs.
516 European ancestry lymphoblastoid cell lines
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