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Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.

de Rooy DP, Tsonaka R, Andersson ML et al.

26077402 PubMed ID
GWAS Study Type
515 Participants
71 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

DR
de Rooy DP
TR
Tsonaka R
AM
Andersson ML
FK
Forslind K
ZA
Zhernakova A
FM
Frank-Bertoncelj M
DK
de Kovel CG
KB
Koeleman BP
VD
van der Heijde DM
HT
Huizinga TW
TR
Toes RE
HJ
Houwing-Duistermaat JJ
OC
Ospelt C
SB
Svensson B
VD
van der Helm-van Mil AH
Chapter II

Abstract

Summary of the research findings

Objective: Rheumatoid arthritis (RA) that is negative for anticitrullinated protein antibodies (ACPA) is a subentity of RA, characterized by less severe disease. At the individual level, however, considerable differences in the severity of joint destruction occur. We performed a study on genetic factors underlying the differences in joint destruction in ACPA-negative patients.

262 Western European ancestry cases

Chapter III

Study Statistics

Key metrics and study information

515
Total Participants
GWAS
Study Type
Yes
Replicated
253 Western European ancestry cases
Replication Participants
European
Ancestry
Netherlands, Sweden
Recruitment Country
Chapter IV

AI-Generated Summary

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