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A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.

Bei JX, Su WH, Ng CC et al.

26545403 PubMed ID
GWAS Study Type
15987 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BJ
Bei JX
SW
Su WH
NC
Ng CC
YK
Yu K
CY
Chin YM
LP
Lou PJ
HW
Hsu WL
MJ
McKay JD
CC
Chen CJ
CY
Chang YS
CL
Chen LZ
CM
Chen MY
CQ
Cui Q
FF
Feng FT
FQ
Feng QS
GY
Guo YM
JW
Jia WH
KA
Khoo AS
LW
Liu WS
MH
Mo HY
PK
Pua KC
TS
Teo SH
TK
Tse KP
XY
Xia YF
ZH
Zhang H
ZG
Zhou GQ
LJ
Liu JJ
ZY
Zeng YX
HA
Hildesheim A
Chapter II

Abstract

Summary of the research findings

Genetic loci within the major histocompatibility complex (MHC) have been associated with nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated cancer, in several GWAS. Results outside this region have varied.

2,152 Chinese ancestry cases, 3,740 Chinese ancestry controls

Chapter III

Study Statistics

Key metrics and study information

15987
Total Participants
GWAS
Study Type
Yes
Replicated
4,716 Chinese ancestry cases, 5,379 Chinese ancestry controls
Replication Participants
East Asian
Ancestry
China, Malaysia, Taiwan
Recruitment Country
Chapter IV

AI-Generated Summary

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