A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.
Watanabe H, Atsuta N, Hirakawa A et al.
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Abstract
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Objective: To classify the patterns of functional decline in patients with sporadic amyotrophic lateral sclerosis (ALS) and explore the genetic backgrounds that modified these patterns.
59 Japanese ancestry cases with rapid functional decline, 110 Japanese ancestry cases with intermediate functional decline, 70 Japanese ancestry cases with sigmoidal functional decline, 215 Japanese ancestry cases with moderate functional decline
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