CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk.
Garcia-Albeniz X, Rudolph A, Hutter C et al.
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Abstract
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Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene-environment interaction analysis to identify genetic modifiers of CRC risk associated with use of MHT.
1,436 European ancestry postmenopausal cases, 1,948 European ancestry postmenopausal controls
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