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A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma.

Magrangeas F, Kuiper R, Avet-Loiseau H et al.

27060151 PubMed ID
GWAS Study Type
583 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MF
Magrangeas F
KR
Kuiper R
AH
Avet-Loiseau H
GW
Gouraud W
GC
Guérin-Charbonnel C
FL
Ferrer L
AA
Aussem A
EH
Elghazel H
SJ
Suhard J
SH
Sakissian H
AM
Attal M
CM
C Munshi N
SP
Sonneveld P
DC
Dumontet C
MP
Moreau P
VD
van Duin M
CL
Campion L
MS
Minvielle S
Chapter II

Abstract

Summary of the research findings

Purpose: Painful peripheral neuropathy is a frequent toxicity associated with bortezomib therapy. This study aimed to identify loci that affect susceptibility to this toxicity.

155 French ancestry cases, 314 French ancestry controls

Chapter III

Study Statistics

Key metrics and study information

583
Total Participants
GWAS
Study Type
Yes
Replicated
40 European ancestry cases, 74 European ancestry controls
Replication Participants
European
Ancestry
France, Netherlands, Germany
Recruitment Country
Chapter IV

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