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GWAS Study

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Jones GT, Tromp G, Kuivaniemi H et al.

27899403 PubMed ID
GWAS Study Type
117970 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

JG
Jones GT
TG
Tromp G
KH
Kuivaniemi H
GS
Gretarsdottir S
BA
Baas AF
GB
Giusti B
SE
Strauss E
VH
Van't Hof FN
WT
Webb TR
ER
Erdman R
RM
Ritchie MD
EJ
Elmore JR
VA
Verma A
PS
Pendergrass S
KI
Kullo IJ
YZ
Ye Z
PP
Peissig PL
GO
Gottesman O
VS
Verma SS
MJ
Malinowski J
RL
Rasmussen-Torvik LJ
BK
Borthwick KM
SD
Smelser DT
CD
Crosslin DR
DA
de Andrade M
RE
Ryer EJ
MC
McCarty CA
BE
Böttinger EP
PJ
Pacheco JA
CD
Crawford DC
CD
Carrell DS
GG
Gerhard GS
FD
Franklin DP
CD
Carey DJ
PV
Phillips VL
WM
Williams MJ
WW
Wei W
BR
Blair R
HA
Hill AA
VT
Vasudevan TM
LD
Lewis DR
TI
Thomson IA
KJ
Krysa J
HG
Hill GB
RJ
Roake J
MT
Merriman TR
OG
Oszkinis G
GS
Galora S
SC
Saracini C
AR
Abbate R
PR
Pulli R
PC
Pratesi C
SA
Saratzis A
VA
Verissimo AR
BS
Bumpstead S
BS
Badger SA
CR
Clough RE
CG
Cockerill G
HH
Hafez H
SD
Scott DJ
FT
Futers TS
RS
Romaine SP
BK
Bridge K
GK
Griffin KJ
BM
Bailey MA
SA
Smith A
TM
Thompson MM
VB
van Bockxmeer FM
MS
Matthiasson SE
TG
Thorleifsson G
TU
Thorsteinsdottir U
BJ
Blankensteijn JD
TJ
Teijink JA
WC
Wijmenga C
DG
de Graaf J
KL
Kiemeney LA
LJ
Lindholt JS
HA
Hughes A
BD
Bradley DT
SK
Stirrups K
GJ
Golledge J
NP
Norman PE
PJ
Powell JT
HS
Humphries SE
HS
Hamby SE
GA
Goodall AH
NC
Nelson CP
SN
Sakalihasan N
CA
Courtois A
FR
Ferrell RE
EP
Eriksson P
FL
Folkersen L
FA
Franco-Cereceda A
EJ
Eicher JD
JA
Johnson AD
BC
Betsholtz C
RA
Ruusalepp A
FO
Franzén O
SE
Schadt EE
BJ
Björkegren JL
LL
Lipovich L
DA
Drolet AM
VE
Verhoeven EL
ZC
Zeebregts CJ
GR
Geelkerken RH
VS
van Sambeek MR
VS
van Sterkenburg SM
DV
de Vries JP
SK
Stefansson K
TJ
Thompson JR
DB
de Bakker PI
DP
Deloukas P
SR
Sayers RD
HS
Harrison SC
VR
van Rij AM
SN
Samani NJ
BM
Bown MJ
Chapter II

Abstract

Summary of the research findings

Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA.

4,972 European ancestry cases, 99,858 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

117970
Total Participants
GWAS
Study Type
Yes
Replicated
2,482 European ancestry cases, 2,750 cases, 2,645 European ancestry controls, 5,263 controls
Replication Participants
European
Ancestry
U.S., Australia, U.K., Iceland, Netherlands, New Zealand, Poland, Italy, Canada, Belgium
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.