Genome-Wide Association Study for Anthracycline-Induced Congestive Heart Failure.
Schneider BP, Shen F, Gardner L et al.
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Purpose: Anthracycline-induced congestive heart failure (CHF) is a rare but serious toxicity associated with this commonly employed anticancer therapy. The ability to predict which patients might be at increased risk prior to exposure would be valuable to optimally counsel risk-to-benefit ratio for each patient. Herein, we present a genome-wide approach for biomarker discovery with two validation cohorts to predict CHF from adult patients planning to receive anthracycline.
51 European American ancestry cases, 794 European American ancestry controls
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