Novel genetic loci associated with hippocampal volume.
Hibar DP, Adams HHH, Jahanshad N et al.
Publication Details
Comprehensive information about this research publication
Authors
Abstract
Summary of the research findings
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
26,814 European ancestry individuals
Study Statistics
Key metrics and study information
AI-Generated Summary
AI-generated by DNAGENICSIndependent AI summary of health and genetic findings from the published study
Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.
AI Summary In Progress
Our AI-generated summary of this publication is being prepared. Please check back soon.
Summary
Key Findings
Health Insights
Disease Analysis
Genetic Trait Analysis
Clinical Relevance
Related Publications
Other publications that may be of interest
HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement.
Farashi S
Nat Commun
Age-related macular degeneration with reticular pseudodrusen
Genetic Insights into Head-to-Body Ratios Via Deep Learning-Based Image Segmentation and Implications for Common Diseases.
Shi W
Nat Commun
Head width to hip width ratio
A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men.
Rosenthal SB
Nat Commun
Chronic prostatitis/chronic pelvic pain syndrome
Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure.
Nicholls HL
Nat Commun
Body surface area-indexed left ventricular end-systolic volume or Body surface area-indexed left ventricular end-diastolic volume (MTAG)
The genetic basis of dermatophytosis skin infection susceptibility.
Haapaniemi H
Nat Commun
ICD10 B35: Dermatophytosis
Explore More Research
Discover the latest findings in health and genetic research