Linking Alzheimer's disease and type 2 diabetes: Novel shared susceptibility genes detected by cFDR approach.
Wang XF, Lin X, Li DY et al.
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Abstract
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Both type 2 diabetes (T2D) and Alzheimer's disease (AD) occur commonly in the aging populations and T2D has been considered as an important risk factor for AD. The heritability of both diseases is estimated to be over 50%. However, common pleiotropic single-nucleotide polymorphisms (SNPs)/loci have not been well-defined. The aim of this study is to analyze two large public accessible GWAS datasets to identify novel common genetic loci for T2D and/or AD.
17,008 European ancestry Alzheimer's disease cases, 12,171 European ancestry type II diabetes cases, 94,016 European ancestry controls
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