A variant in PPP4R3A protects against alzheimer-related metabolic decline.
Christopher L, Napolioni V, Khan RR et al.
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Objectives: A reduction in glucose metabolism in the posterior cingulate cortex (PCC) predicts conversion to Alzheimer's disease (AD) and tracks disease progression, signifying its importance in AD. We aimed to use decline in PCC glucose metabolism as a proxy for the development and progression of AD to discover common genetic variants associated with disease vulnerability.
335 European ancestry MCI cases, 79 European ancestry AD cases, 192 European ancestry controls
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