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GWAS Study

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.

Alonso N, Estrada K, Albagha OME et al.

29170203 PubMed ID
GWAS Study Type
10683 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

AN
Alonso N
EK
Estrada K
AO
Albagha OME
HL
Herrera L
RS
Reppe S
OO
Olstad OK
GK
Gautvik KM
RN
Ryan NM
EK
Evans KL
NC
Nielson CM
HY
Hsu YH
KD
Kiel DP
MG
Markozannes G
NE
Ntzani EE
EE
Evangelou E
FB
Feenstra B
LX
Liu X
MM
Melbye M
ML
Masi L
BM
Brandi ML
RP
Riches P
DA
Daroszewska A
OJ
Olmos JM
VC
Valero C
CJ
Castillo J
RJ
Riancho JA
HL
Husted LB
LB
Langdahl BL
BM
Brown MA
DE
Duncan EL
KS
Kaptoge S
KK
Khaw KT
UR
Usategui-Martín R
DP
Del Pino-Montes J
GR
González-Sarmiento R
LJ
Lewis JR
PR
Prince RL
DP
D'Amelio P
GN
García-Giralt N
NX
Nogués X
MS
Mencej-Bedrac S
MJ
Marc J
WO
Wolstein O
EJ
Eisman JA
OL
Oei L
MC
Medina-Gómez C
SK
Schraut KE
NP
Navarro P
WJ
Wilson JF
DG
Davies G
SJ
Starr J
DI
Deary I
TT
Tanaka T
FL
Ferrucci L
GF
Gianfrancesco F
GL
Gennari L
LG
Lucas G
ER
Elosua R
UA
Uitterlinden AG
RF
Rivadeneira F
RS
Ralston SH
Chapter II

Abstract

Summary of the research findings

Objectives: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis.

1,553 European ancestry cases, 4,340 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

10683
Total Participants
GWAS
Study Type
Yes
Replicated
694 European ancestry cases, 2,105 European ancestry controls, 334 cases, 1,657 controls
Replication Participants
European
Ancestry
U.K., Italy, Spain, Australia, Denmark, Slovenia
Recruitment Country
Chapter IV

AI-Generated Summary

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