Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach.
Kotnik P, Knapič E, Kokošar J et al.
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Abstract
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Recently, we witnessed great progress in the discovery of genetic variants associated with obesity and type 2 diabetes (T2D), especially in adults. Much less is known regarding genetic variants associated with insulin resistance (IR). We hypothesized that novel IR genes could be efficiently detected in a population of obese children and adolescents who may not exhibit comorbidities and other confounding factors.
98 cases, 100 controls
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