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GWAS Study

A novel variant in GLIS3 is associated with osteoarthritis.

Casalone E, Tachmazidou I, Zengini E et al.

29436472 PubMed ID
GWAS Study Type
122717 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CE
Casalone E
TI
Tachmazidou I
ZE
Zengini E
HK
Hatzikotoulas K
HS
Hackinger S
SD
Suveges D
SJ
Steinberg J
RN
Rayner NW
WJ
Wilkinson JM
PK
Panoutsopoulou K
ZE
Zeggini E
Chapter II

Abstract

Summary of the research findings

Objectives: Osteoarthritis (OA) is a complex disease, but its genetic aetiology remains poorly characterised. To identify novel susceptibility loci for OA, we carried out a genome-wide association study (GWAS) in individuals from the largest UK-based OA collections to date.

5,414 European ancestry cases, 9,939 European ancestry healthy controls

Chapter III

Study Statistics

Key metrics and study information

122717
Total Participants
GWAS
Study Type
Yes
Replicated
17,894 European ancestry cases, 89,470 European ancestry healthy controls
Replication Participants
European
Ancestry
U.K.
Recruitment Country
Chapter IV

AI-Generated Summary

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Independent AI summary of health and genetic findings from the published study

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