Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
Shrine N, Portelli MA, John C et al.
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Abstract
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Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.
5,135 European ancestry cases, 25,675 European ancestry controls
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