Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.
Márquez A, Kerick M, Zhernakova A et al.
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Abstract
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In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component.
11,489 European ancestry cases with celiac disease, 15,523 European ancestry cases with rheumatoid arthritis, 3,477 European ancestry cases with systemic sclerosis, 6,670 European ancestry cases with type 1 diabetes, 22,308 European ancestry controls
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