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GWAS Study

Genetic Variants Associated with Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome Wide Association Studies.

Oetting WS, Wu B, Schladt DP et al.

30801552 PubMed ID
GWAS Study Type
2442 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

OW
Oetting WS
WB
Wu B
SD
Schladt DP
GW
Guan W
VS
van Setten J
KB
Keating BJ
ID
Iklé D
RR
Remmel RP
DC
Dorr CR
MR
Mannon RB
MA
Matas AJ
IA
Israni AK
JP
Jacobson PA
Chapter II

Abstract

Summary of the research findings

The immunosuppressants tacrolimus and mycophenolate are important components to the success of organ transplantation, but are also associated with adverse effects, such as nephrotoxicity, anemia, leukopenia, and new-onset diabetes after transplantation. In this report, we attempted to identify genetic variants which are associated with these adverse outcomes.

1,363 European ancestry individuals, 299 African American individuals

Chapter III

Study Statistics

Key metrics and study information

2442
Total Participants
GWAS
Study Type
Yes
Replicated
609 European ancestry individuals, 171 African American individuals
Replication Participants
European, African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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