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GWAS Study

An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients.

Min S, Papaz T, Lambert AN et al.

33755393 PubMed ID
GWAS Study Type
777 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MS
Min S
PT
Papaz T
LA
Lambert AN
AU
Allen U
BP
Birk P
BT
Blydt-Hansen T
FB
Foster BJ
GH
Grasemann H
HL
Hamiwka L
LC
Litalien C
NV
Ng V
BN
Berka N
CP
Campbell P
DC
Daniel C
SC
Saw CL
TK
Tinckam K
US
Urschel S
VD
Van Driest SL
PR
Parekh R
MS
Mital S
Chapter II

Abstract

Summary of the research findings

There are challenges in achieving and maintaining therapeutic tacrolimus levels after solid organ transplantation (SOT). The purpose of this genome-wide association study was to generate an integrated clinical and genetic prediction model for tacrolimus levels in pediatric SOT.

287 White ancestry children, 18 Black children, 89 Asian ancestry children, 14 Aboriginal ancestry children, 47 children

Chapter III

Study Statistics

Key metrics and study information

777
Total Participants
GWAS
Study Type
Yes
Replicated
249 White ancestry children, 19 Black children, 30 Asian ancestry children, 12 Aboriginal ancestry children, 12 children
Replication Participants
European, African American or Afro-Caribbean, Asian unspecified, Native American
Ancestry
Canada
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

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